DegronMD - Q96ED9(HOOK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R714H	TCGA-AP-A059	UCEC	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714H	TCGA-D1-A16X	UCEC	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714H	DO41799	UCEC	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714H	DO41361	UCEC	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.K718T	TCGA-D7-A6EY	STAD	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation substituting flanking lysine	0.1944
p.K718T	DO50118	STAD	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation substituting flanking lysine	0.1944
p.R702C	TCGA-G4-6309	COAD	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.8301
p.R702C	DO7810	COAD	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.8301
p.R702C	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.8301
p.R702C	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.8301
p.R714C	DO232761	PBCA	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714C	SIDM01149	Small Cell Lung Carcinoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714C	NCI-H847	lung	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.R714C	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1944
p.G703E	SIDM00841	Colorectal Carcinoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.6087
p.G703E	SW620	large intestine	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.6087
p.R701H	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.7133
p.R701H	CRO-AP3	NS	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.7133
p.N712S	SIDM01525	Acute Myeloid Leukemia	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.25
p.G701E	ACH-000651	Colon/Colorectal Cancer	CCLE	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.7199
p.G701E	SW620	large intestine	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.7199
p.A695T	ACH-002026	Endometrial/Uterine Cancer	CCLE	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.1667
p.R700C	ACH-002222	Leukemia	CCLE	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.3056
p.R700C	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.3056
p.R699H	CRO-AP3	NS	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.2778
p.R712C	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.25
p.R712C	NCI-H847	lung	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.25
p.R702H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.8244
p.R700H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	701:709	Mutation rewiring degron network	0.3056

Kaplan plot for HOOK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HOOK2

UniProt ID: Q96ED9

Entrez ID: 29911

Protein name: Protein Hook homolog 2 (h-hook2) (hHK2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HOOK2 in