DegronMD

Uniprot ID: Q96ED9

Source protein: Protein Hook homolog 2

Source gene: HOOK2

Class: DEG_APCC_DBOX_1

Location: 701:709

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8554

ASA_SCORE: 90.3667

COIL: 0.8216

CONS_SCORE: 0.2285

DSS_SCORE: 0.5658

HELIX: 0.136

FCONS_SCORE: 0.6681

RIG_SCORE: 0.6698

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R714H	TCGA-AP-A059	UCEC	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714H	TCGA-D1-A16X	UCEC	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714H	DO41799	UCEC	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714H	DO41361	UCEC	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.K718T	TCGA-D7-A6EY	STAD	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.K718T	DO50118	STAD	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R702C	TCGA-G4-6309	COAD	TCGA	RRGPLGRLA	DEG_APCC_DBOX_1	0.8301
p.R702C	DO7810	COAD	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	0.8301
p.R702C	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	0.8301
p.R702C	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.8301
p.R714C	DO232761	PBCA	ICGC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714C	SIDM01149	Small Cell Lung Carcinoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714C	NCI-H847	lung	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.R714C	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.1944
p.G703E	SIDM00841	Colorectal Carcinoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	0.6087
p.G703E	SW620	large_intestine	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.6087
p.R701H	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	0.7133
p.R701H	CRO-AP3	NS	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.7133
p.N712S	SIDM01525	Acute Myeloid Leukemia	GDSC	RRGPLGRLA	DEG_APCC_DBOX_1	0.25
p.G701E	ACH-000651	Colon/Colorectal Cancer	CCLE	RRGPLGRLA	DEG_APCC_DBOX_1	0.7199
p.G701E	SW620	large_intestine	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.7199
p.A695T	ACH-002026	Endometrial/Uterine Cancer	CCLE	RRGPLGRLA	DEG_APCC_DBOX_1	0.1667
p.R700C	ACH-002222	Leukemia	CCLE	RRGPLGRLA	DEG_APCC_DBOX_1	0.3056
p.R700C	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.3056
p.R699H	CRO-AP3	NS	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.2778
p.R712C	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.25
p.R712C	NCI-H847	lung	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.25
p.R702H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.8244
p.R700H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRGPLGRLA	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRGPLGRLA

Degron related mutations and impact score

Drug responses associated with HOOK2 mutations

All proteins holding degron of RRGPLGRLA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ED9	Protein Hook homolog 2	DEG_APCC_DBOX_1	701:709	RRGPLGRLA	APC,CDC20,FZR1	0.8554	More...