DegronMD - Q96EE4(CCDC126)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S136P	TCGA-A5-A0G2	UCEC	TCGA	SIR	DEG_APCC_TPR_1	138:140	Mutation blocking phosphorylation signal	0.7222
p.S136P	DO41235	UCEC	ICGC	SIR	DEG_APCC_TPR_1	138:140	Mutation blocking phosphorylation signal	0.7222
p.T133M	TCGA-AA-A010	COAD	TCGA	SIR	DEG_APCC_TPR_1	138:140	Mutation rewiring degron network	0.1944
p.T133M	TCGA-HQ-A2OE	BLCA	TCGA	SIR	DEG_APCC_TPR_1	138:140	Mutation rewiring degron network	0.1944
p.T133M	DO540	BLCA	ICGC	SIR	DEG_APCC_TPR_1	138:140	Mutation rewiring degron network	0.1944
p.I139V	DO233878	GACA	ICGC	SIR	DEG_APCC_TPR_1	138:140	Mutation altering degron motif	0.7076
p.R132K	DO222402	MELA	ICGC	SIR	DEG_APCC_TPR_1	138:140	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons