DegronMD

Uniprot ID: Q96EE4

Source protein: Coiled-coil domain-containing protein 126

Source gene: CCDC126

Class: DEG_APCC_TPR_1

Location: 138:140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9595

ASA_SCORE: 124.7

COIL: 0.8907

CONS_SCORE: 0.575

DSS_SCORE: 0.9327

HELIX: 0.0663

FCONS_SCORE: 1.0385

RIG_SCORE: 0.7308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S136P	TCGA-A5-A0G2	UCEC	TCGA	SIR	DEG_APCC_TPR_1	0.7222
p.S136P	DO41235	UCEC	ICGC	SIR	DEG_APCC_TPR_1	0.7222
p.T133M	TCGA-AA-A010	COAD	TCGA	SIR	DEG_APCC_TPR_1	0.1944
p.T133M	TCGA-HQ-A2OE	BLCA	TCGA	SIR	DEG_APCC_TPR_1	0.1944
p.T133M	DO540	BLCA	ICGC	SIR	DEG_APCC_TPR_1	0.1944
p.I139V	DO233878	GACA	ICGC	SIR	DEG_APCC_TPR_1	0.7076
p.R132K	DO222402	MELA	ICGC	SIR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM13	Anaphase-promoting complex subunit 10	DEG_APCC_TPR_1	183:185	SIR	APC,CDC20,FZR1	0.9858	More...
Q5JVG8	Zinc finger protein 506	DEG_APCC_TPR_1	442:444	SIR	APC,CDC20,FZR1	0.9835	More...
Q96EE4	Coiled-coil domain-containing protein 126	DEG_APCC_TPR_1	138:140	SIR	APC,CDC20,FZR1	0.9595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons