DegronMD

Uniprot ID: Q5JVG8

Source protein: Zinc finger protein 506

Source gene: ZNF506

Class: DEG_APCC_TPR_1

Location: 442:444

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9835

ASA_SCORE: 114.6

COIL: 0.9793

CONS_SCORE: 0.3965

DSS_SCORE: 0.6608

HELIX: 0.0073

FCONS_SCORE: 0.9883

RIG_SCORE: 0.8222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L433F	TCGA-AA-3984	COAD	TCGA	SIR	DEG_APCC_TPR_1	0.0833
p.L433F	DO9002	COAD	ICGC	SIR	DEG_APCC_TPR_1	0.0833
p.R444G	TCGA-DD-AADS	LIHC	TCGA	SIR	DEG_APCC_TPR_1	0.7568
p.Q438R	DO233823	GACA	ICGC	SIR	DEG_APCC_TPR_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM13	Anaphase-promoting complex subunit 10	DEG_APCC_TPR_1	183:185	SIR	APC,CDC20,FZR1	0.9858	More...
Q5JVG8	Zinc finger protein 506	DEG_APCC_TPR_1	442:444	SIR	APC,CDC20,FZR1	0.9835	More...
Q96EE4	Coiled-coil domain-containing protein 126	DEG_APCC_TPR_1	138:140	SIR	APC,CDC20,FZR1	0.9595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons