DegronMD - Q9UM13(ANAPC10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q155H	TCGA-06-5416	GBM	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.25
p.Q155H	DO10880	GBM	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.25
p.R182H	TCGA-A5-A0G2	UCEC	TCGA	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.3056
p.R182H	TCGA-B5-A11E	UCEC	TCGA	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.3056
p.R182H	DO41644	UCEC	ICGC	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.3056
p.R182H	DO41235	UCEC	ICGC	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.3056
p.P171T	TCGA-AA-A010	COAD	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.1389
p.G148R	TCGA-AA-A010	COAD	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.0556
p.F178L	TCGA-AT-A5NU	KIRP	TCGA	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.1944
p.F178L	DO49729	KIRP	ICGC	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.1944
p.E164D	TCGA-BK-A6W3	UCEC	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation altering degron motif	0.6758
p.E164D	DO50076	UCEC	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation altering degron motif	0.6758
p.Y181F	TCGA-BR-8487	STAD	TCGA	SIR	DEG_APCC_TPR_1	183:185	Mutation blocking phosphorylation signal	0.7222
p.Y181F	DO47867	STAD	ICGC	SIR	DEG_APCC_TPR_1	183:185	Mutation blocking phosphorylation signal	0.7222
p.Y159C	TCGA-DU-6392	LGG	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation altering degron motif	0.5976
p.Y159C	DO22237	LGG	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation altering degron motif	0.5976
p.K169T	TCGA-EO-A3B0	UCEC	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation blocking ubiquitination signal	0.6389
p.K169T	DO219773	UCEC	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation blocking ubiquitination signal	0.6389
p.S166C	TCGA-MA-AA3Z	CESC	TCGA	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.2778
p.S166C	DO219722	CESC	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.2778
p.I176V	TCGA-OR-A5J6	ACC	TCGA	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.1389
p.T174K	DO229041	LICA	ICGC	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.0833
p.T174K	DO229041	LICA	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.0556
p.P171S	DO220899	MELA	ICGC	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.1389
p.D177Y	DO232224	PBCA	ICGC	SIR	DEG_APCC_TPR_1	183:185	Mutation rewiring degron network	0.1667
p.T151S	ACH-000887	Brain Cancer	CCLE	IYTPVEE	DEG_SCF_FBW7_2	158:164	Mutation rewiring degron network	0.1389

Kaplan plot for ANAPC10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANAPC10

UniProt ID: Q9UM13

Entrez ID: 10393

Protein name: Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANAPC10 in