DegronMD

Uniprot ID: Q9UM13

Source protein: Anaphase-promoting complex subunit 10

Source gene: ANAPC10

Class: DEG_APCC_TPR_1

Location: 183:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9858

ASA_SCORE: 102.9333

COIL: 0.8447

CONS_SCORE: 0.5784

DSS_SCORE: 0.6954

HELIX: 0.1273

FCONS_SCORE: 1.6814

RIG_SCORE: 0.8571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R182H	TCGA-A5-A0G2	UCEC	TCGA	SIR	DEG_APCC_TPR_1	0.3056
p.R182H	TCGA-B5-A11E	UCEC	TCGA	SIR	DEG_APCC_TPR_1	0.3056
p.R182H	DO41644	UCEC	ICGC	SIR	DEG_APCC_TPR_1	0.3056
p.R182H	DO41235	UCEC	ICGC	SIR	DEG_APCC_TPR_1	0.3056
p.F178L	TCGA-AT-A5NU	KIRP	TCGA	SIR	DEG_APCC_TPR_1	0.1944
p.F178L	DO49729	KIRP	ICGC	SIR	DEG_APCC_TPR_1	0.1944
p.Y181F	TCGA-BR-8487	STAD	TCGA	SIR	DEG_APCC_TPR_1	0.7222
p.Y181F	DO47867	STAD	ICGC	SIR	DEG_APCC_TPR_1	0.7222
p.I176V	TCGA-OR-A5J6	ACC	TCGA	SIR	DEG_APCC_TPR_1	0.1389
p.T174K	DO229041	LICA	ICGC	SIR	DEG_APCC_TPR_1	0.0833
p.D177Y	DO232224	PBCA	ICGC	SIR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM13	Anaphase-promoting complex subunit 10	DEG_APCC_TPR_1	183:185	SIR	APC,CDC20,FZR1	0.9858	More...
Q5JVG8	Zinc finger protein 506	DEG_APCC_TPR_1	442:444	SIR	APC,CDC20,FZR1	0.9835	More...
Q96EE4	Coiled-coil domain-containing protein 126	DEG_APCC_TPR_1	138:140	SIR	APC,CDC20,FZR1	0.9595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons