DegronMD

Uniprot ID: Q9UM13

Source protein: Anaphase-promoting complex subunit 10

Source gene: ANAPC10

Class: DEG_SCF_FBW7_2

Location: 158:164

E3 ligase: FBXW7

DEGRON score: 0.8866

ASA_SCORE: 62.7714

COIL: 0.5779

CONS_SCORE: 0.4376

DSS_SCORE: 0.3393

HELIX: 0.0409

FCONS_SCORE: 0.8411

RIG_SCORE: 0.8128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q155H	TCGA-06-5416	GBM	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.25
p.Q155H	DO10880	GBM	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.25
p.P171T	TCGA-AA-A010	COAD	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.1389
p.G148R	TCGA-AA-A010	COAD	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.0556
p.E164D	TCGA-BK-A6W3	UCEC	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.6758
p.E164D	DO50076	UCEC	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.6758
p.Y159C	TCGA-DU-6392	LGG	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.5976
p.Y159C	DO22237	LGG	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.5976
p.K169T	TCGA-EO-A3B0	UCEC	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.6389
p.K169T	DO219773	UCEC	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.6389
p.S166C	TCGA-MA-AA3Z	CESC	TCGA	IYTPVEE	DEG_SCF_FBW7_2	0.2778
p.S166C	DO219722	CESC	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.2778
p.T174K	DO229041	LICA	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.0556
p.P171S	DO220899	MELA	ICGC	IYTPVEE	DEG_SCF_FBW7_2	0.1389
p.T151S	ACH-000887	Brain Cancer	CCLE	IYTPVEE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UM13	Anaphase-promoting complex subunit 10	DEG_SCF_FBW7_2	158:164	IYTPVEE	FBXW7	0.8866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons