DegronMD - Q96EF0(MTMR8)

MTMR8

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R187C	TCGA-59-2349	OV	TCGA	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1111
p.R187C	DO28621	OV	ICGC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1111
p.A201T	TCGA-DI-A1BU	UCEC	TCGA	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.2778
p.A201T	DO42023	UCEC	ICGC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.2778
p.R204H	TCGA-FA-A7DS	DLBC	TCGA	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1944
p.R204H	DO219889	DLBC	ICGC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1944
p.R204H	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1944
p.R204H	EC-GI-10	oesophagus	COSMIC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1944
p.R187S	DO228948	LICA	ICGC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1111
p.E186Q	DO50726	ORCA	ICGC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.0833
p.L209P	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.0556
p.L209P	ACH-002256	Leukemia	CCLE	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.0556
p.L209P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.0556
p.V188F	ACH-000237	Ovarian Cancer	CCLE	YKENN	DEG_APCC_KENBOX_2	195:199	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc