DegronMD

Uniprot ID: Q96EF0

Source protein: Myotubularin-related protein 8

Source gene: MTMR8

Class: DEG_APCC_KENBOX_2

Location: 195:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6379

ASA_SCORE: 72.12

COIL: 0.7294

CONS_SCORE: 0.4898

DSS_SCORE: 0.05

HELIX: 0.0534

FCONS_SCORE: 0.6635

RIG_SCORE: 0.8771

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R187C	TCGA-59-2349	OV	TCGA	YKENN	DEG_APCC_KENBOX_2	0.1111
p.R187C	DO28621	OV	ICGC	YKENN	DEG_APCC_KENBOX_2	0.1111
p.A201T	TCGA-DI-A1BU	UCEC	TCGA	YKENN	DEG_APCC_KENBOX_2	0.2778
p.A201T	DO42023	UCEC	ICGC	YKENN	DEG_APCC_KENBOX_2	0.2778
p.R204H	TCGA-FA-A7DS	DLBC	TCGA	YKENN	DEG_APCC_KENBOX_2	0.1944
p.R204H	DO219889	DLBC	ICGC	YKENN	DEG_APCC_KENBOX_2	0.1944
p.R204H	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	YKENN	DEG_APCC_KENBOX_2	0.1944
p.R204H	EC-GI-10	oesophagus	COSMIC	YKENN	DEG_APCC_KENBOX_2	0.1944
p.R187S	DO228948	LICA	ICGC	YKENN	DEG_APCC_KENBOX_2	0.1111
p.E186Q	DO50726	ORCA	ICGC	YKENN	DEG_APCC_KENBOX_2	0.0833
p.L209P	SIDM01007	T-Lymphoblastic Leukemia	GDSC	YKENN	DEG_APCC_KENBOX_2	0.0556
p.L209P	ACH-002256	Leukemia	CCLE	YKENN	DEG_APCC_KENBOX_2	0.0556
p.L209P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	YKENN	DEG_APCC_KENBOX_2	0.0556
p.V188F	ACH-000237	Ovarian Cancer	CCLE	YKENN	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EF0	Myotubularin-related protein 8	DEG_APCC_KENBOX_2	195:199	YKENN	APC,CDC20,FZR1	0.6379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons