DegronMD - Q96EH3(MALSU1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F215L	TCGA-CQ-5326	HNSC	TCGA	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation altering degron motif	0.587
p.F215L	DO15286	HNSC	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation altering degron motif	0.587
p.P228L	TCGA-EE-A29M	SKCM	TCGA	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation rewiring degron network	0.0833
p.P228L	DO37404	SKCM	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation rewiring degron network	0.0833
p.Y199C	TCGA-IB-7651	PAAD	TCGA	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation rewiring degron network	0.1389
p.Y199C	DO46657	PAAD	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation rewiring degron network	0.1389
p.Q202R	DO233885	GACA	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation rewiring degron network	0.2222
p.R197H	SIDM00697	Small Cell Lung Carcinoma	GDSC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	206:219	Mutation rewiring degron network	0.0833

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons