DegronMD

Uniprot ID: Q96EH3

Source protein: Mitochondrial assembly of ribosomal large subunit protein 1

Source gene: MALSU1

Class: DEG_ODPH_VHL_1

Location: 206:219

E3 ligase: VHL

DEGRON score: 0.9835

ASA_SCORE: 68.15

COIL: 0.7316

CONS_SCORE: 0.3615

DSS_SCORE: 0.3816

HELIX: 0.2143

FCONS_SCORE: 1.1021

RIG_SCORE: 0.8116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F215L	TCGA-CQ-5326	HNSC	TCGA	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.587
p.F215L	DO15286	HNSC	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.587
p.P228L	TCGA-EE-A29M	SKCM	TCGA	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.0833
p.P228L	DO37404	SKCM	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.0833
p.Y199C	TCGA-IB-7651	PAAD	TCGA	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.1389
p.Y199C	DO46657	PAAD	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.1389
p.Q202R	DO233885	GACA	ICGC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.2222
p.R197H	SIDM00697	Small Cell Lung Carcinoma	GDSC	IAPETVPEDFILGI	DEG_ODPH_VHL_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EH3	Mitochondrial assembly of ribosomal large subunit protein 1	DEG_ODPH_VHL_1	206:219	IAPETVPEDFILGI	VHL	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons