DegronMD - Q96EK9(KTI12)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A186T	TCGA-06-5416	GBM	TCGA	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.3056
p.A186T	DO10880	GBM	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.3056
p.S200Y	TCGA-2W-A8YY	CESC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking phosphorylation signal	0.5833
p.S200Y	DO223732	CESC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking phosphorylation signal	0.5833
p.S200F	TCGA-60-2721	LUSC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking phosphorylation signal	0.5833
p.S200F	DO26447	LUSC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking phosphorylation signal	0.5833
p.S179C	TCGA-DS-A1OB	CESC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking phosphorylation signal	0.5556
p.S179C	DO6323	CESC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking phosphorylation signal	0.5556
p.E193D	TCGA-EO-A3AY	UCEC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.6758
p.E193D	DO43202	UCEC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.6758
p.K197M	TCGA-EO-A3B0	UCEC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking ubiquitination signal	0.6667
p.K197M	DO219773	UCEC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation blocking ubiquitination signal	0.6667
p.D191E	DO229013	COCA	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.5647
p.D191E	DO229003	COCA	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.5647
p.D191E	DO229489	LAML	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.5647
p.D191E	DO225404	LAML	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.5647
p.G199R	DO228640	PRAD	ICGC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.1667
p.T189S	SIDM01123	Prostate Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.8227
p.T189S	SIDM01409	Bladder Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.8227
p.H198R	SIDM00985	Burkitt's Lymphoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.1944
p.H198R	SIDM01722	Non-Cancerous	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.1944
p.H198R	SIDM00174	Head and Neck Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.1944
p.H198R	SIDM00899	Pancreatic Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.1944
p.L187H	SIDM00654	Small Cell Lung Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.7313
p.L187H	NCI-H1048	lung	COSMIC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation altering degron motif	0.7313
p.P185A	SIDM00489	Oral Cavity Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.2778
p.P185A	ACH-002043	Head and Neck Cancer	CCLE	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.2778
p.P185A	Ca9-22	upper aerodigestive tract	COSMIC	LVTPDSE	DEG_SCF_FBW7_2	187:193	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KTI12

UniProt ID: Q96EK9

Entrez ID: 112970

Protein name: Protein KTI12 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KTI12 in