DegronMD

Uniprot ID: Q96EK9

Source protein: Protein KTI12 homolog

Source gene: KTI12

Class: DEG_SCF_FBW7_2

Location: 187:193

E3 ligase: FBXW7

DEGRON score: 0.9785

ASA_SCORE: 62.3286

COIL: 0.7379

CONS_SCORE: 0.0794

DSS_SCORE: 0.6368

HELIX: 0.1179

FCONS_SCORE: 0.5809

RIG_SCORE: 0.6513

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A186T	TCGA-06-5416	GBM	TCGA	LVTPDSE	DEG_SCF_FBW7_2	0.3056
p.A186T	DO10880	GBM	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.3056
p.S200Y	TCGA-2W-A8YY	CESC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	0.5833
p.S200Y	DO223732	CESC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5833
p.S200F	TCGA-60-2721	LUSC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	0.5833
p.S200F	DO26447	LUSC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5833
p.S179C	TCGA-DS-A1OB	CESC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	0.5556
p.S179C	DO6323	CESC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5556
p.E193D	TCGA-EO-A3AY	UCEC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	0.6758
p.E193D	DO43202	UCEC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.6758
p.K197M	TCGA-EO-A3B0	UCEC	TCGA	LVTPDSE	DEG_SCF_FBW7_2	0.6667
p.K197M	DO219773	UCEC	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.6667
p.D191E	DO229013	COCA	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5647
p.D191E	DO229003	COCA	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5647
p.D191E	DO229489	LAML	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5647
p.D191E	DO225404	LAML	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.5647
p.G199R	DO228640	PRAD	ICGC	LVTPDSE	DEG_SCF_FBW7_2	0.1667
p.T189S	SIDM01123	Prostate Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.8227
p.T189S	SIDM01409	Bladder Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.8227
p.H198R	SIDM00985	Burkitt's Lymphoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.1944
p.H198R	SIDM01722	Non-Cancerous	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.1944
p.H198R	SIDM00174	Head and Neck Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.1944
p.H198R	SIDM00899	Pancreatic Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.1944
p.L187H	SIDM00654	Small Cell Lung Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.7313
p.L187H	NCI-H1048	lung	COSMIC	LVTPDSE	DEG_SCF_FBW7_2	0.7313
p.P185A	SIDM00489	Oral Cavity Carcinoma	GDSC	LVTPDSE	DEG_SCF_FBW7_2	0.2778
p.P185A	ACH-002043	Head and Neck Cancer	CCLE	LVTPDSE	DEG_SCF_FBW7_2	0.2778
p.P185A	Ca9-22	upper_aerodigestive_tract	COSMIC	LVTPDSE	DEG_SCF_FBW7_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVTPDSE

Degron related mutations and impact score

Drug responses associated with KTI12 mutations

All proteins holding degron of LVTPDSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EK9	Protein KTI12 homolog	DEG_SCF_FBW7_2	187:193	LVTPDSE	FBXW7	0.9785	More...