DegronMD - Q96EV2(RBM33)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S727C	TCGA-EK-A3GK	CESC	TCGA	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2778
p.S727C	DO49964	CESC	ICGC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2778
p.S727C	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2778
p.S727C	ACH-000787	Lung Cancer	CCLE	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2778
p.S727C	LXF-289	lung	COSMIC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2778
p.R725H	TCGA-FI-A2D4	UCEC	TCGA	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2222
p.R725H	DO43170	UCEC	ICGC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.2222
p.A740V	DO230323	COCA	ICGC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.25
p.A740V	DO222571	COCA	ICGC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.25
p.A740T	DO233270	GACA	ICGC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.25
p.P742S	SIDM01169	Ovarian Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1944
p.P742S	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1944
p.P742S	SIDM00518	Mesothelioma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1944
p.P742S	SIDM00462	Acute Myeloid Leukemia	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1944
p.P742S	SIDM01760	Rhabdomyosarcoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1944
p.P743T	SIDM01199	Hepatocellular Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1667
p.S723G	SIDM00860	Head and Neck Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1667
p.S723G	FADU	upper aerodigestive tract	COSMIC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1667
p.P736H	SIDM00596	Endometrial Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation altering degron motif	0.7694
p.P736H	ACH-001517	Endometrial/Uterine Cancer	CCLE	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation altering degron motif	0.7694
p.P736H	HEC-1	endometrium	COSMIC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation altering degron motif	0.7694
p.R745Q	SIDM01608	Endometrial Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1111
p.R745Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	TPSAQVKPI	DEG_SIAH_1	729:737	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM33

UniProt ID: Q96EV2

Entrez ID: 155435

Protein name: RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM33 in