DegronMD

Uniprot ID: Q96EV2

Source protein: RNA-binding protein 33

Source gene: RBM33

Class: DEG_SIAH_1

Location: 729:737

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9901

ASA_SCORE: 98.2222

COIL: 0.8903

CONS_SCORE: 0.5443

DSS_SCORE: 0.535

HELIX: 0.0647

FCONS_SCORE: 1.4362

RIG_SCORE: 0.6728

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P736H	SIDM00596	Endometrial Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.7694
p.P736H	ACH-001517	Endometrial/Uterine Cancer	CCLE	TPSAQVKPI	DEG_SIAH_1	0.7694
p.P736H	HEC-1	endometrium	COSMIC	TPSAQVKPI	DEG_SIAH_1	0.7694
p.S727C	TCGA-EK-A3GK	CESC	TCGA	TPSAQVKPI	DEG_SIAH_1	0.2778
p.S727C	DO49964	CESC	ICGC	TPSAQVKPI	DEG_SIAH_1	0.2778
p.S727C	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.2778
p.S727C	ACH-000787	Lung Cancer	CCLE	TPSAQVKPI	DEG_SIAH_1	0.2778
p.S727C	LXF-289	lung	COSMIC	TPSAQVKPI	DEG_SIAH_1	0.2778
p.A740V	DO230323	COCA	ICGC	TPSAQVKPI	DEG_SIAH_1	0.25
p.A740V	DO222571	COCA	ICGC	TPSAQVKPI	DEG_SIAH_1	0.25
p.A740T	DO233270	GACA	ICGC	TPSAQVKPI	DEG_SIAH_1	0.25
p.R725H	TCGA-FI-A2D4	UCEC	TCGA	TPSAQVKPI	DEG_SIAH_1	0.2222
p.R725H	DO43170	UCEC	ICGC	TPSAQVKPI	DEG_SIAH_1	0.2222
p.P742S	SIDM01169	Ovarian Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1944
p.P742S	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1944
p.P742S	SIDM00518	Mesothelioma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1944
p.P742S	SIDM00462	Acute Myeloid Leukemia	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1944
p.P742S	SIDM01760	Rhabdomyosarcoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1944
p.P743T	SIDM01199	Hepatocellular Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1667
p.S723G	SIDM00860	Head and Neck Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1667
p.S723G	FADU	upper_aerodigestive_tract	COSMIC	TPSAQVKPI	DEG_SIAH_1	0.1667
p.R745Q	SIDM01608	Endometrial Carcinoma	GDSC	TPSAQVKPI	DEG_SIAH_1	0.1111
p.R745Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	TPSAQVKPI	DEG_SIAH_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EV2	RNA-binding protein 33	DEG_SIAH_1	729:737	TPSAQVKPI	SIAH1,SIAH2,SIAH3	0.9901	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons