DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
TPSAQVKPI
Uniprot ID:
Q96EV2
Source protein:
RNA-binding protein 33
Source gene:
RBM33
Class:
DEG_SIAH_1
Location:
729:737
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.9901
ASA_SCORE:
98.2222
COIL:
0.8903
CONS_SCORE:
0.5443
DSS_SCORE:
0.535
HELIX:
0.0647
FCONS_SCORE:
1.4362
RIG_SCORE:
0.6728
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S727C
TCGA-EK-A3GK
CESC
TCGA
TPSAQVKPI
DEG_SIAH_1
0.2778
p.S727C
DO49964
CESC
ICGC
TPSAQVKPI
DEG_SIAH_1
0.2778
p.S727C
SIDM00339
Non-Small Cell Lung Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.2778
p.S727C
ACH-000787
Lung Cancer
CCLE
TPSAQVKPI
DEG_SIAH_1
0.2778
p.S727C
LXF-289
lung
COSMIC
TPSAQVKPI
DEG_SIAH_1
0.2778
p.R725H
TCGA-FI-A2D4
UCEC
TCGA
TPSAQVKPI
DEG_SIAH_1
0.2222
p.R725H
DO43170
UCEC
ICGC
TPSAQVKPI
DEG_SIAH_1
0.2222
p.A740V
DO230323
COCA
ICGC
TPSAQVKPI
DEG_SIAH_1
0.25
p.A740V
DO222571
COCA
ICGC
TPSAQVKPI
DEG_SIAH_1
0.25
p.A740T
DO233270
GACA
ICGC
TPSAQVKPI
DEG_SIAH_1
0.25
p.P742S
SIDM01169
Ovarian Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1944
p.P742S
SIDM00751
Non-Small Cell Lung Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1944
p.P742S
SIDM00518
Mesothelioma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1944
p.P742S
SIDM00462
Acute Myeloid Leukemia
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1944
p.P742S
SIDM01760
Rhabdomyosarcoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1944
p.P743T
SIDM01199
Hepatocellular Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1667
p.S723G
SIDM00860
Head and Neck Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1667
p.S723G
FADU
upper_aerodigestive_tract
COSMIC
TPSAQVKPI
DEG_SIAH_1
0.1667
p.P736H
SIDM00596
Endometrial Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.7694
p.P736H
ACH-001517
Endometrial/Uterine Cancer
CCLE
TPSAQVKPI
DEG_SIAH_1
0.7694
p.P736H
HEC-1
endometrium
COSMIC
TPSAQVKPI
DEG_SIAH_1
0.7694
p.R745Q
SIDM01608
Endometrial Carcinoma
GDSC
TPSAQVKPI
DEG_SIAH_1
0.1111
p.R745Q
ACH-000990
Endometrial/Uterine Cancer
CCLE
TPSAQVKPI
DEG_SIAH_1
0.1111
Drug responses associated with RBM33 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TPSAQVKPI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96EV2
RNA-binding protein 33
DEG_SIAH_1
729:737
TPSAQVKPI
SIAH1,SIAH2,SIAH3
0.9901
More...