DegronMD - Q96F07(CYFIP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S582R	TCGA-E1-A7YE	LGG	TCGA	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation altering degron motif	0.7427
p.D571G	DO223592	BLCA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.1111
p.V588F	DO229026	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.3056
p.G571C	DO229034	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.1111
p.G571C	DO229008	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.1111
p.R576L	DO229037	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.25
p.G585V	DO24970	LUAD	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation altering degron motif	0.7532
p.E578K	DO223665	LUAD	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.3056
p.D597N	DO222702	MELA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation blocking ubiquitination signal	0.5
p.M585I	DO37782	SKCM	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation altering degron motif	0.6507
p.P582H	DO41235	UCEC	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation altering degron motif	0.7694
p.T588I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.3056
p.T588I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.3056
p.A595V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.1111
p.A595V	NCI-H1155	lung	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.1111
p.S592F	ACH-000835	Sarcoma	CCLE	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation blocking phosphorylation signal	0.6389
p.S592F	GCT	soft tissue	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation blocking phosphorylation signal	0.6389
p.N580D	ACH-000972	Endometrial/Uterine Cancer	CCLE	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation altering degron motif	0.6932
p.S597F	HN	upper aerodigestive tract	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation blocking ubiquitination signal	0.5
p.L579M	LNCaP-Clone-FGC	prostate	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation altering degron motif	0.711
p.Y576F	MZ1-PC	pancreas	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.25
p.S576C	PFSK-1	central nervous system	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.25
p.A570V	NCI-H1155	lung	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	579:587	Mutation rewiring degron network	0.0833

Kaplan plot for CYFIP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CYFIP2

UniProt ID: Q96F07

Entrez ID: 26999

Protein name: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CYFIP2 in