DegronMD

Uniprot ID: Q96F07

Source protein: Cytoplasmic FMR1-interacting protein 2

Source gene: CYFIP2

Class: DEG_APCC_DBOX_1

Location: 579:587

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7727

ASA_SCORE: 35.0222

COIL: 0.1084

CONS_SCORE: 0.3548

DSS_SCORE: 0.2598

HELIX: 0.883

FCONS_SCORE: 1.2735

RIG_SCORE: 0.8755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S582R	TCGA-E1-A7YE	LGG	TCGA	CRSLLYMVR	DEG_APCC_DBOX_1	0.7427
p.D571G	DO223592	BLCA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.1111
p.V588F	DO229026	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.3056
p.G571C	DO229034	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.1111
p.G571C	DO229008	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.1111
p.R576L	DO229037	LICA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.25
p.G585V	DO24970	LUAD	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.7532
p.E578K	DO223665	LUAD	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.3056
p.D597N	DO222702	MELA	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.5
p.M585I	DO37782	SKCM	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.6507
p.P582H	DO41235	UCEC	ICGC	CRSLLYMVR	DEG_APCC_DBOX_1	0.7694
p.T588I	SIDM01007	T-Lymphoblastic Leukemia	GDSC	CRSLLYMVR	DEG_APCC_DBOX_1	0.3056
p.T588I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.3056
p.A595V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	CRSLLYMVR	DEG_APCC_DBOX_1	0.1111
p.A595V	NCI-H1155	lung	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.1111
p.S592F	ACH-000835	Sarcoma	CCLE	CRSLLYMVR	DEG_APCC_DBOX_1	0.6389
p.S592F	GCT	soft_tissue	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.6389
p.N580D	ACH-000972	Endometrial/Uterine Cancer	CCLE	CRSLLYMVR	DEG_APCC_DBOX_1	0.6932
p.S597F	HN	upper_aerodigestive_tract	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.5
p.L579M	LNCaP-Clone-FGC	prostate	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.711
p.Y576F	MZ1-PC	pancreas	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.25
p.S576C	PFSK-1	central_nervous_system	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.25
p.A570V	NCI-H1155	lung	COSMIC	CRSLLYMVR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F07	Cytoplasmic FMR1-interacting protein 2	DEG_APCC_DBOX_1	579:587	CRSLLYMVR	APC,CDC20,FZR1	0.7727	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons