DegronMD - Q96F24(NRBF2)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P232S	TCGA-17-Z031	LUAD	TCGA	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation altering degron motif	0.6752
p.T242N	TCGA-29-1691	OV	TCGA	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.1389
p.S229N	TCGA-AX-A0J1	UCEC	TCGA	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.3056
p.E235Q	TCGA-K4-AAQO	BLCA	TCGA	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation altering degron motif	0.6744
p.E225Q	DO219030	BLCA	ICGC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.1944
p.A237P	DO229016	COCA	ICGC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.2778
p.A237P	FU-OV-1	ovary	COSMIC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.2778
p.T232N	DO32133	OV	ICGC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation altering degron motif	0.7055
p.G241V	DO37631	SKCM	ICGC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.1667
p.A238S	DO41235	UCEC	ICGC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.25
p.A238T	OC-314	ovary	COSMIC	LPPHAE	LIG_APCC_ABBA_1	230:235	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons