DegronMD

Uniprot ID: Q96F24

Source protein: Nuclear receptor-binding factor 2

Source gene: NRBF2

Class: LIG_APCC_ABBA_1

Location: 230:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.997

ASA_SCORE: 75.7

COIL: 0.8135

CONS_SCORE: 0.4465

DSS_SCORE: 0.4776

HELIX: 0.1072

FCONS_SCORE: 1.0895

RIG_SCORE: 0.7296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P232S	TCGA-17-Z031	LUAD	TCGA	LPPHAE	LIG_APCC_ABBA_1	0.6752
p.T242N	TCGA-29-1691	OV	TCGA	LPPHAE	LIG_APCC_ABBA_1	0.1389
p.S229N	TCGA-AX-A0J1	UCEC	TCGA	LPPHAE	LIG_APCC_ABBA_1	0.3056
p.E235Q	TCGA-K4-AAQO	BLCA	TCGA	LPPHAE	LIG_APCC_ABBA_1	0.6744
p.E225Q	DO219030	BLCA	ICGC	LPPHAE	LIG_APCC_ABBA_1	0.1944
p.A237P	DO229016	COCA	ICGC	LPPHAE	LIG_APCC_ABBA_1	0.2778
p.A237P	FU-OV-1	ovary	COSMIC	LPPHAE	LIG_APCC_ABBA_1	0.2778
p.T232N	DO32133	OV	ICGC	LPPHAE	LIG_APCC_ABBA_1	0.7055
p.G241V	DO37631	SKCM	ICGC	LPPHAE	LIG_APCC_ABBA_1	0.1667
p.A238S	DO41235	UCEC	ICGC	LPPHAE	LIG_APCC_ABBA_1	0.25
p.A238T	OC-314	ovary	COSMIC	LPPHAE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F24	Nuclear receptor-binding factor 2	LIG_APCC_ABBA_1	230:235	LPPHAE	APC,CDC20,FZR1	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons