DegronMD - Q96F46(IL17RA)

FUNCTION: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:24120361, PubMed:17911633, PubMed:18684971, PubMed:21350122). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). {ECO:0000250|UniProtKB:Q60943, ECO:0000269|PubMed:16785495, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19838198, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:9367539}.; FUNCTION: (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway. {ECO:0000269|PubMed:33723527}. View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P778S	TCGA-FI-A2D5	UCEC	TCGA	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation altering degron motif	0.6752
p.P778S	DO41331	UCEC	ICGC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation altering degron motif	0.6752
p.S792Y	TCGA-FX-A3NJ	SARC	TCGA	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation blocking phosphorylation signal	0.5556
p.S792Y	DO220118	SARC	ICGC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation blocking phosphorylation signal	0.5556
p.T780M	DO233088	GACA	ICGC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation altering degron motif	0.8534
p.R787W	DO232224	PBCA	ICGC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.25
p.Q791R	SIDM00333	Endometrial Carcinoma	GDSC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.1389
p.Q791R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.1389
p.Q794L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.0556
p.Q794L	ACH-000917	Esophageal Cancer	CCLE	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.0556
p.Q794L	TE-4	oesophagus	COSMIC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.0556
p.D793G	ACH-000930	Breast Cancer	CCLE	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.0833
p.T775M	MFE-319	endometrium	COSMIC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.25
p.P768S	NCI-H2172	lung	COSMIC	PHTPYEE	DEG_SCF_FBW7_2	778:784	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL17RA

UniProt ID: Q96F46

Entrez ID: 23765

Protein name: Interleukin-17 receptor A (IL-17 receptor A) (IL-17RA) (CDw217) (CD antigen CD217)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL17RA in