DegronMD

Uniprot ID: Q96F46

Source protein: Interleukin-17 receptor A

Source gene: IL17RA

Class: DEG_SCF_FBW7_2

Location: 778:784

E3 ligase: FBXW7

DEGRON score: 0.8047

ASA_SCORE: 100.3

COIL: 0.7866

CONS_SCORE: 0.3229

DSS_SCORE: 0.6674

HELIX: 0.1803

FCONS_SCORE: 0.8711

RIG_SCORE: 0.6934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P778S	TCGA-FI-A2D5	UCEC	TCGA	PHTPYEE	DEG_SCF_FBW7_2	0.6752
p.P778S	DO41331	UCEC	ICGC	PHTPYEE	DEG_SCF_FBW7_2	0.6752
p.S792Y	TCGA-FX-A3NJ	SARC	TCGA	PHTPYEE	DEG_SCF_FBW7_2	0.5556
p.S792Y	DO220118	SARC	ICGC	PHTPYEE	DEG_SCF_FBW7_2	0.5556
p.T780M	DO233088	GACA	ICGC	PHTPYEE	DEG_SCF_FBW7_2	0.8534
p.R787W	DO232224	PBCA	ICGC	PHTPYEE	DEG_SCF_FBW7_2	0.25
p.Q791R	SIDM00333	Endometrial Carcinoma	GDSC	PHTPYEE	DEG_SCF_FBW7_2	0.1389
p.Q791R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PHTPYEE	DEG_SCF_FBW7_2	0.1389
p.Q794L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PHTPYEE	DEG_SCF_FBW7_2	0.0556
p.Q794L	ACH-000917	Esophageal Cancer	CCLE	PHTPYEE	DEG_SCF_FBW7_2	0.0556
p.Q794L	TE-4	oesophagus	COSMIC	PHTPYEE	DEG_SCF_FBW7_2	0.0556
p.D793G	ACH-000930	Breast Cancer	CCLE	PHTPYEE	DEG_SCF_FBW7_2	0.0833
p.T775M	MFE-319	endometrium	COSMIC	PHTPYEE	DEG_SCF_FBW7_2	0.25
p.P768S	NCI-H2172	lung	COSMIC	PHTPYEE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F46	Interleukin-17 receptor A	DEG_SCF_FBW7_2	778:784	PHTPYEE	FBXW7	0.8047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons