DegronMD - Q96F63(CCDC97)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R30W	TCGA-AX-A1CE	UCEC	TCGA	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.7523
p.R30W	DO42280	UCEC	ICGC	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.7523
p.Q38K	TCGA-BF-A1Q0	SKCM	TCGA	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.25
p.Q38K	DO47374	SKCM	ICGC	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.25
p.R30Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.6218
p.R30Q	NCI-H2172	lung	COSMIC	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation altering degron motif	0.6218
p.D39N	SIDM00003	Melanoma	GDSC	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2222
p.D39N	ACH-000884	Skin Cancer	CCLE	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2222
p.D39N	ACH-002159	Skin Cancer	CCLE	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2222
p.D39N	M14	skin	COSMIC	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.2222
p.G21V	ACH-001366	Neuroblastoma	CCLE	LSRTPVPS	DEG_SCF_FBW7_1	28:35	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons