DegronMD

Uniprot ID: Q96F63

Source protein: Coiled-coil domain-containing protein 97

Source gene: CCDC97

Class: DEG_SCF_FBW7_1

Location: 28:35

E3 ligase: FBXW7

DEGRON score: 0.9167

ASA_SCORE: 90.1875

COIL: 0.9201

CONS_SCORE: 0.2296

DSS_SCORE: 0.6936

HELIX: 0.0185

FCONS_SCORE: 0.8793

RIG_SCORE: 0.6419

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30W	TCGA-AX-A1CE	UCEC	TCGA	LSRTPVPS	DEG_SCF_FBW7_1	0.7523
p.R30W	DO42280	UCEC	ICGC	LSRTPVPS	DEG_SCF_FBW7_1	0.7523
p.Q38K	TCGA-BF-A1Q0	SKCM	TCGA	LSRTPVPS	DEG_SCF_FBW7_1	0.25
p.Q38K	DO47374	SKCM	ICGC	LSRTPVPS	DEG_SCF_FBW7_1	0.25
p.R30Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LSRTPVPS	DEG_SCF_FBW7_1	0.6218
p.R30Q	NCI-H2172	lung	COSMIC	LSRTPVPS	DEG_SCF_FBW7_1	0.6218
p.D39N	SIDM00003	Melanoma	GDSC	LSRTPVPS	DEG_SCF_FBW7_1	0.2222
p.D39N	ACH-000884	Skin Cancer	CCLE	LSRTPVPS	DEG_SCF_FBW7_1	0.2222
p.D39N	ACH-002159	Skin Cancer	CCLE	LSRTPVPS	DEG_SCF_FBW7_1	0.2222
p.D39N	M14	skin	COSMIC	LSRTPVPS	DEG_SCF_FBW7_1	0.2222
p.G21V	ACH-001366	Neuroblastoma	CCLE	LSRTPVPS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F63	Coiled-coil domain-containing protein 97	DEG_SCF_FBW7_1	28:35	LSRTPVPS	FBXW7	0.9167	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons