DegronMD - Q96FK6(WDR89)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A132S	TCGA-05-4424	LUAD	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.0556
p.A132S	DO23672	LUAD	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.0556
p.E135D	TCGA-AJ-A5DW	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.1389
p.E135D	DO50075	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.1389
p.A141V	TCGA-AP-A051	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.3056
p.A141V	TCGA-BS-A0UV	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.3056
p.A141V	DO42793	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.3056
p.A141V	DO42673	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.3056
p.S152Y	TCGA-AX-A2HC	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.1944
p.S152Y	DO41572	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.1944
p.R149M	TCGA-D3-A3CE	SKCM	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.2778
p.R149M	DO37405	SKCM	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.2778
p.L142W	TCGA-LK-A4O6	MESO	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.7015
p.L142W	TCGA-SC-A6LP	MESO	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.7015
p.A148V	TCGA-NH-A5IV	COAD	TCGA	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.3056
p.A148V	DO49095	COAD	ICGC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.3056
p.V144G	SIDM01078	Small Cell Lung Carcinoma	GDSC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.7532
p.V144G	ACH-000790	Lung Cancer	CCLE	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.7532
p.V144G	SHP-77	lung	COSMIC	LLVFWD	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.7532

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR89

UniProt ID: Q96FK6

Entrez ID: 112840

Protein name: WD repeat-containing protein 89

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR89 in