DegronMD

Uniprot ID: Q96FK6

Source protein: WD repeat-containing protein 89

Source gene: WDR89

Class: LIG_APCC_ABBA_1

Location: 142:147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8731

ASA_SCORE: 9.5833

COIL: 0.0573

CONS_SCORE: 0.5596

DSS_SCORE: 0.1605

HELIX: 0.0048

FCONS_SCORE: 1.333

RIG_SCORE: 0.9714

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A132S	TCGA-05-4424	LUAD	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.0556
p.A132S	DO23672	LUAD	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.0556
p.E135D	TCGA-AJ-A5DW	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.1389
p.E135D	DO50075	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.1389
p.A141V	TCGA-AP-A051	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.3056
p.A141V	TCGA-BS-A0UV	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.3056
p.A141V	DO42793	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.3056
p.A141V	DO42673	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.3056
p.S152Y	TCGA-AX-A2HC	UCEC	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.1944
p.S152Y	DO41572	UCEC	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.1944
p.R149M	TCGA-D3-A3CE	SKCM	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.2778
p.R149M	DO37405	SKCM	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.2778
p.L142W	TCGA-LK-A4O6	MESO	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.7015
p.L142W	TCGA-SC-A6LP	MESO	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.7015
p.A148V	TCGA-NH-A5IV	COAD	TCGA	LLVFWD	LIG_APCC_ABBA_1	0.3056
p.A148V	DO49095	COAD	ICGC	LLVFWD	LIG_APCC_ABBA_1	0.3056
p.V144G	SIDM01078	Small Cell Lung Carcinoma	GDSC	LLVFWD	LIG_APCC_ABBA_1	0.7532
p.V144G	ACH-000790	Lung Cancer	CCLE	LLVFWD	LIG_APCC_ABBA_1	0.7532
p.V144G	SHP-77	lung	COSMIC	LLVFWD	LIG_APCC_ABBA_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FK6	WD repeat-containing protein 89	LIG_APCC_ABBA_1	142:147	LLVFWD	APC,CDC20,FZR1	0.8731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons