DegronMD - Q96FT7(ASIC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E410K	TCGA-18-3409	LUSC	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.1667
p.E410K	TCGA-EB-A5UN	SKCM	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.1667
p.E410K	DO26444	LUSC	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.1667
p.E410K	DO47267	SKCM	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.1667
p.P419S	TCGA-58-8387	LUSC	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.6752
p.P419S	TCGA-BG-A222	UCEC	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.6752
p.P419S	DO45445	LUSC	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.6752
p.P419S	DO42977	UCEC	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.6752
p.R412W	TCGA-BR-4368	STAD	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222
p.R412W	DO232761	PBCA	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222
p.R412W	DO38715	STAD	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222
p.E431K	TCGA-EE-A29L	SKCM	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.0556
p.E431K	DO222599	MELA	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.0556
p.E431K	DO37835	SKCM	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.0556
p.W420L	TCGA-W5-AA39	CHOL	TCGA	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.7015
p.R424H	DO229505	LAML	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.25
p.P417T	DO50888	LICA	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.7031
p.P417T	SIDM00537	Colorectal Carcinoma	GDSC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.7031
p.P417T	ACH-000982	Colon/Colorectal Cancer	CCLE	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.7031
p.P417T	ACH-001345	Colon/Colorectal Cancer	CCLE	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.7031
p.P417T	GP5d	large intestine	COSMIC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation altering degron motif	0.7031
p.E426K	DO220899	MELA	ICGC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.1944
p.A425T	SIDM00454	Rhabdomyosarcoma	GDSC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222
p.A425T	SIDM00254	Neuroblastoma	GDSC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222
p.A425S	SIDM00561	Other Blood Cancers	GDSC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222
p.A425S	MLMA	haematopoietic and lymphoid tissue	COSMIC	LDVFFE	LIG_APCC_ABBA_1	416:421	Mutation rewiring degron network	0.2222

Kaplan plot for ASIC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASIC4

UniProt ID: Q96FT7

Entrez ID: 55515

Protein name: Acid-sensing ion channel 4 (ASIC4) (Amiloride-sensitive cation channel 4) (Amiloride-sensitive cation channel 4, pituitary)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASIC4 in