DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
LDVFFE
Uniprot ID:
Q96FT7
Source protein:
Acid-sensing ion channel 4
Source gene:
ASIC4
Class:
LIG_APCC_ABBA_1
Location:
416:421
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5682
ASA_SCORE:
39.2667
COIL:
0.171
CONS_SCORE:
0.6784
DSS_SCORE:
0.0308
HELIX:
0.024
FCONS_SCORE:
1.5097
RIG_SCORE:
0.9991
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E410K
TCGA-18-3409
LUSC
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.1667
p.E410K
TCGA-EB-A5UN
SKCM
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.1667
p.E410K
DO26444
LUSC
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.1667
p.E410K
DO47267
SKCM
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.1667
p.P419S
TCGA-58-8387
LUSC
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.6752
p.P419S
TCGA-BG-A222
UCEC
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.6752
p.P419S
DO45445
LUSC
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.6752
p.P419S
DO42977
UCEC
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.6752
p.R412W
TCGA-BR-4368
STAD
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.2222
p.R412W
DO232761
PBCA
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.2222
p.R412W
DO38715
STAD
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.2222
p.E431K
TCGA-EE-A29L
SKCM
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.0556
p.E431K
DO222599
MELA
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.0556
p.E431K
DO37835
SKCM
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.0556
p.W420L
TCGA-W5-AA39
CHOL
TCGA
LDVFFE
LIG_APCC_ABBA_1
0.7015
p.R424H
DO229505
LAML
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.25
p.P417T
DO50888
LICA
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.7031
p.P417T
SIDM00537
Colorectal Carcinoma
GDSC
LDVFFE
LIG_APCC_ABBA_1
0.7031
p.P417T
ACH-000982
Colon/Colorectal Cancer
CCLE
LDVFFE
LIG_APCC_ABBA_1
0.7031
p.P417T
ACH-001345
Colon/Colorectal Cancer
CCLE
LDVFFE
LIG_APCC_ABBA_1
0.7031
p.P417T
GP5d
large_intestine
COSMIC
LDVFFE
LIG_APCC_ABBA_1
0.7031
p.E426K
DO220899
MELA
ICGC
LDVFFE
LIG_APCC_ABBA_1
0.1944
p.A425T
SIDM00454
Rhabdomyosarcoma
GDSC
LDVFFE
LIG_APCC_ABBA_1
0.2222
p.A425T
SIDM00254
Neuroblastoma
GDSC
LDVFFE
LIG_APCC_ABBA_1
0.2222
p.A425S
SIDM00561
Other Blood Cancers
GDSC
LDVFFE
LIG_APCC_ABBA_1
0.2222
p.A425S
MLMA
haematopoietic_and_lymphoid_tissue
COSMIC
LDVFFE
LIG_APCC_ABBA_1
0.2222
Drug responses associated with ASIC4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LDVFFE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96FT7
Acid-sensing ion channel 4
LIG_APCC_ABBA_1
416:421
LDVFFE
APC,CDC20,FZR1
0.5682
More...