DegronMD

Uniprot ID: Q96FT7

Source protein: Acid-sensing ion channel 4

Source gene: ASIC4

Class: LIG_APCC_ABBA_1

Location: 416:421

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5682

ASA_SCORE: 39.2667

COIL: 0.171

CONS_SCORE: 0.6784

DSS_SCORE: 0.0308

HELIX: 0.024

FCONS_SCORE: 1.5097

RIG_SCORE: 0.9991

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P417T	DO50888	LICA	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.7031
p.P417T	SIDM00537	Colorectal Carcinoma	GDSC	LDVFFE	LIG_APCC_ABBA_1	0.7031
p.P417T	ACH-000982	Colon/Colorectal Cancer	CCLE	LDVFFE	LIG_APCC_ABBA_1	0.7031
p.P417T	ACH-001345	Colon/Colorectal Cancer	CCLE	LDVFFE	LIG_APCC_ABBA_1	0.7031
p.P417T	GP5d	large_intestine	COSMIC	LDVFFE	LIG_APCC_ABBA_1	0.7031
p.W420L	TCGA-W5-AA39	CHOL	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.7015
p.P419S	TCGA-58-8387	LUSC	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.6752
p.P419S	TCGA-BG-A222	UCEC	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.6752
p.P419S	DO45445	LUSC	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.6752
p.P419S	DO42977	UCEC	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.6752
p.R424H	DO229505	LAML	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.25
p.R412W	TCGA-BR-4368	STAD	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.R412W	DO232761	PBCA	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.R412W	DO38715	STAD	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.A425T	SIDM00454	Rhabdomyosarcoma	GDSC	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.A425T	SIDM00254	Neuroblastoma	GDSC	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.A425S	SIDM00561	Other Blood Cancers	GDSC	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.A425S	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	LDVFFE	LIG_APCC_ABBA_1	0.2222
p.E426K	DO220899	MELA	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.1944
p.E410K	TCGA-18-3409	LUSC	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.1667
p.E410K	TCGA-EB-A5UN	SKCM	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.1667
p.E410K	DO26444	LUSC	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.1667
p.E410K	DO47267	SKCM	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.1667
p.E431K	TCGA-EE-A29L	SKCM	TCGA	LDVFFE	LIG_APCC_ABBA_1	0.0556
p.E431K	DO222599	MELA	ICGC	LDVFFE	LIG_APCC_ABBA_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FT7	Acid-sensing ion channel 4	LIG_APCC_ABBA_1	416:421	LDVFFE	APC,CDC20,FZR1	0.5682	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons