DegronMD - Q96FV2(SCRN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D296V	TCGA-04-1362	OV	TCGA	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.0833
p.I276M	TCGA-AC-A23H	BRCA	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.25
p.R284H	TCGA-AP-A1DK	UCEC	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.7133
p.R284H	TCGA-AX-A2HD	UCEC	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.7133
p.S280L	TCGA-AP-A1DV	UCEC	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.8778
p.S288I	TCGA-AX-A2HD	UCEC	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.25
p.R284C	TCGA-AX-A2IN	UCEC	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.719
p.R284C	TCGA-EE-A29L	SKCM	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.719
p.R284C	SIDM00210	Ovarian Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.719
p.R284C	SIDM00808	Burkitt's Lymphoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.719
p.R284C	SIDM01254	Burkitt's Lymphoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.719
p.L269V	TCGA-DD-A73G	LIHC	TCGA	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.0556
p.I284M	DO2401	BRCA	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation altering degron motif	0.7618
p.V272A	DO233885	GACA	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation blocking ubiquitination signal	0.5833
p.L277V	DO48473	LIHC	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.2778
p.R292C	DO222599	MELA	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1389
p.R292C	DO37835	SKCM	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1389
p.R292C	DO42328	UCEC	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1389
p.D304V	DO30260	OV	ICGC	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.3056
p.R292H	DO42033	UCEC	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1389
p.R292H	DO42608	UCEC	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1389
p.S288L	DO43186	UCEC	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.25
p.E271G	DO41871	UCEC	ICGC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1111
p.S296I	DO42608	UCEC	ICGC	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.0833
p.E273Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00433	T-Lymphoblastic Leukemia	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00087	Plasma Cell Myeloma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00633	Breast Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00879	Breast Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00383	Gastric Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00214	Colorectal Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00032	Bladder Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00997	Thyroid Gland Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM01147	Gastric Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM01133	Other Solid Cancers	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00068	Colorectal Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00479	Esophageal Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM01613	Colorectal Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM00167	Head and Neck Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.E273Q	SIDM01664	Prostate Carcinoma	GDSC	DSGGFRT	DEG_SCF_TRCP1_1	279:285	Mutation rewiring degron network	0.1667
p.S312F	SIDM00789	Colorectal Carcinoma	GDSC	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.7982
p.S312F	ACH-000997	Colon/Colorectal Cancer	CCLE	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.7982
p.S312F	HCT-15	large intestine	COSMIC	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation altering degron motif	0.7982
p.S320F	HCT-15	large intestine	COSMIC	LTATPDPS	DEG_SCF_FBW7_1	305:312	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCRN2

UniProt ID: Q96FV2

Entrez ID: 90507

Protein name: Secernin-2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCRN2 in