DegronMD

Uniprot ID: Q96FV2

Source protein: Secernin-2

Source gene: SCRN2

Class: DEG_SCF_FBW7_1

Location: 305:312

E3 ligase: FBXW7

DEGRON score: 0.8521

ASA_SCORE: 17.0875

COIL: 0.6974

CONS_SCORE: 0.696

DSS_SCORE: 0.3001

HELIX: 0.0176

FCONS_SCORE: 1.2151

RIG_SCORE: 0.7552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D296V	TCGA-04-1362	OV	TCGA	LTATPDPS	DEG_SCF_FBW7_1	0.0833
p.D304V	DO30260	OV	ICGC	LTATPDPS	DEG_SCF_FBW7_1	0.3056
p.S296I	DO42608	UCEC	ICGC	LTATPDPS	DEG_SCF_FBW7_1	0.0833
p.S312F	SIDM00789	Colorectal Carcinoma	GDSC	LTATPDPS	DEG_SCF_FBW7_1	0.7982
p.S312F	ACH-000997	Colon/Colorectal Cancer	CCLE	LTATPDPS	DEG_SCF_FBW7_1	0.7982
p.S312F	HCT-15	large_intestine	COSMIC	LTATPDPS	DEG_SCF_FBW7_1	0.7982
p.S320F	HCT-15	large_intestine	COSMIC	LTATPDPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FV2	Secernin-2	DEG_SCF_FBW7_1	305:312	LTATPDPS	FBXW7	0.8521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons