DegronMD - Q96FX2(DPH3)

FUNCTION: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250}.; FUNCTION: Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. {ECO:0000269|PubMed:14527407, ECO:0000269|PubMed:14980502}.

GO - Biological processes (BP): negative regulation of protein secretion [GO:0050709]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183]; positive regulation of binding [GO:0051099]; tRNA wobble uridine modification [GO:0002098]

GO - Molecular function (MF): metal ion binding [GO:0046872]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
MAVFHD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	DPH3 homolog	1:6	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E7K	TCGA-E5-A4TZ	BLCA	TCGA	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.E7K	DO44055	BLCA	ICGC	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.3056
p.E11K	TCGA-AC-A23H	BRCA	TCGA	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1944
p.E11K	DO2401	BRCA	ICGC	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.1944
p.Y15D	SIDM00312	Plasma Cell Myeloma	GDSC	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0833
p.Y15D	ACH-000183	Myeloma	CCLE	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0833
p.Y15D	L-363	haematopoietic and lymphoid tissue	COSMIC	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0833
p.D16G	TCGA-B5-A1MW	UCEC	TCGA	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.D16G	DO42913	UCEC	ICGC	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556
p.D16E	DO229032	LICA	ICGC	MAVFHD	LIG_APCC_ABBA_1	1:6	Mutation rewiring degron network	0.0556

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No resistance data available for this Degron.

Kaplan plot for DPH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPH3

UniProt ID: Q96FX2

Entrez ID: 285381

Protein name: DPH3 homolog (CSL-type zinc finger-containing protein 2) (DelGEF-interacting protein 1) (DelGIP1)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for DPH3 in