DegronMD

Uniprot ID: Q96FX2

Source protein: DPH3 homolog

Source gene: DPH3

Class: LIG_APCC_ABBA_1

Location: 1:6

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6352

ASA_SCORE: 93.7833

COIL: 0.8803

CONS_SCORE: 0.5416

DSS_SCORE: 0.7007

HELIX: 0.0082

FCONS_SCORE: 0.7906

RIG_SCORE: 0.8272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E11K	TCGA-AC-A23H	BRCA	TCGA	MAVFHD	LIG_APCC_ABBA_1	0.1944
p.E11K	DO2401	BRCA	ICGC	MAVFHD	LIG_APCC_ABBA_1	0.1944
p.D16G	TCGA-B5-A1MW	UCEC	TCGA	MAVFHD	LIG_APCC_ABBA_1	0.0556
p.D16G	DO42913	UCEC	ICGC	MAVFHD	LIG_APCC_ABBA_1	0.0556
p.E7K	TCGA-E5-A4TZ	BLCA	TCGA	MAVFHD	LIG_APCC_ABBA_1	0.3056
p.E7K	DO44055	BLCA	ICGC	MAVFHD	LIG_APCC_ABBA_1	0.3056
p.D16E	DO229032	LICA	ICGC	MAVFHD	LIG_APCC_ABBA_1	0.0556
p.Y15D	SIDM00312	Plasma Cell Myeloma	GDSC	MAVFHD	LIG_APCC_ABBA_1	0.0833
p.Y15D	ACH-000183	Myeloma	CCLE	MAVFHD	LIG_APCC_ABBA_1	0.0833
p.Y15D	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	MAVFHD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons