DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
MAVFHD
Uniprot ID:
Q9H4G8
Source protein:
Putative DPH3 homolog B
Source gene:
DPH3P1
Class:
LIG_APCC_ABBA_1
Location:
1:6
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5897
ASA_SCORE:
93.1
COIL:
0.8875
CONS_SCORE:
0.5214
DSS_SCORE:
0.7104
HELIX:
0.0087
FCONS_SCORE:
0.7608
RIG_SCORE:
0.8291
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DPH3P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MAVFHD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96FX2
DPH3 homolog
LIG_APCC_ABBA_1
1:6
MAVFHD
APC,CDC20,FZR1
0.6352
More...
Q9H4G8
Putative DPH3 homolog B
LIG_APCC_ABBA_1
1:6
MAVFHD
APC,CDC20,FZR1
0.5897
More...