DegronMD - Q96GG9(DCUN1D1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R53Q	TCGA-06-5416	GBM	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R53Q	TCGA-EE-A3J7	SKCM	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R53Q	DO10880	GBM	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.R53Q	DO48770	SKCM	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.Q76E	TCGA-4Z-AA7M	BLCA	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.Q76E	DO218976	BLCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1389
p.D77Y	TCGA-A5-A1OF	UCEC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.D77Y	TCGA-EO-A3AY	UCEC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.D77Y	DO43202	UCEC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.D77Y	DO42568	UCEC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1111
p.E78D	TCGA-B5-A1MR	UCEC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.E78D	DO229264	THCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.E78D	DO41758	UCEC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.I52V	TCGA-DD-AADA	LIHC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.I52V	DO52227	LIHC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0833
p.R71T	TCGA-DK-A3WW	BLCA	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.R71T	DO481	BLCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.2778
p.K63N	TCGA-F5-6814	READ	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.5806
p.K63N	DO36556	READ	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.5806
p.Q67K	DO228948	LICA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.5833
p.P75A	DO50888	LICA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.1667
p.D61V	DO45175	LIRI	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.6674
p.R62S	DO229275	THCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation altering degron motif	0.7427
p.A79V	ECC10	stomach	COSMIC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0556
p.A79V	SNU-283	large intestine	COSMIC	DRKKLEQLY	DEG_APCC_DBOX_1	61:69	Mutation rewiring degron network	0.0556

Kaplan plot for DCUN1D1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCUN1D1

UniProt ID: Q96GG9

Entrez ID: 54165

Protein name: DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCUN1D1 in