DegronMD

Uniprot ID: Q96GG9

Source protein: DCN1-like protein 1

Source gene: DCUN1D1

Class: DEG_APCC_DBOX_1

Location: 61:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9272

ASA_SCORE: 80.4

COIL: 0.2404

CONS_SCORE: 0.3677

DSS_SCORE: 0.3492

HELIX: 0.7354

FCONS_SCORE: 1.2396

RIG_SCORE: 0.8097

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53Q	TCGA-06-5416	GBM	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.R53Q	TCGA-EE-A3J7	SKCM	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.R53Q	DO10880	GBM	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.R53Q	DO48770	SKCM	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.Q76E	TCGA-4Z-AA7M	BLCA	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.1389
p.Q76E	DO218976	BLCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.1389
p.D77Y	TCGA-A5-A1OF	UCEC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.D77Y	TCGA-EO-A3AY	UCEC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.D77Y	DO43202	UCEC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.D77Y	DO42568	UCEC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.1111
p.E78D	TCGA-B5-A1MR	UCEC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.0833
p.E78D	DO229264	THCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.0833
p.E78D	DO41758	UCEC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.0833
p.I52V	TCGA-DD-AADA	LIHC	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.0833
p.I52V	DO52227	LIHC	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.0833
p.R71T	TCGA-DK-A3WW	BLCA	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.2778
p.R71T	DO481	BLCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.2778
p.K63N	TCGA-F5-6814	READ	TCGA	DRKKLEQLY	DEG_APCC_DBOX_1	0.5806
p.K63N	DO36556	READ	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.5806
p.Q67K	DO228948	LICA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.5833
p.P75A	DO50888	LICA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.1667
p.D61V	DO45175	LIRI	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.6674
p.R62S	DO229275	THCA	ICGC	DRKKLEQLY	DEG_APCC_DBOX_1	0.7427
p.A79V	ECC10	stomach	COSMIC	DRKKLEQLY	DEG_APCC_DBOX_1	0.0556
p.A79V	SNU-283	large_intestine	COSMIC	DRKKLEQLY	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GG9	DCN1-like protein 1	DEG_APCC_DBOX_1	61:69	DRKKLEQLY	APC,CDC20,FZR1	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons