DegronMD - Q96GK7(FAHD2A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F136C	TCGA-19-5956	GBM	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.F136C	DO13863	GBM	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.I140V	TCGA-77-7463	LUSC	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140V	DO26716	LUSC	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.V141M	TCGA-A5-A0G5	UCEC	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6097
p.V141M	TCGA-BR-8487	STAD	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6097
p.V141M	DO47867	STAD	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6097
p.V141M	DO41416	UCEC	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6097
p.V141M	SIDM01297	Colorectal Carcinoma	GDSC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6097
p.S139F	TCGA-AC-A5XS	BRCA	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.S139F	DO50023	BRCA	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.P143S	TCGA-AX-A0J1	UCEC	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6752
p.P143S	DO41199	UCEC	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6752
p.A137V	TCGA-BR-4184	STAD	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2222
p.A137V	DO38328	STAD	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2222
p.E146K	TCGA-CR-7369	HNSC	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7022
p.E146K	DO14934	HNSC	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7022
p.I132S	TCGA-F5-6814	READ	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0833
p.I132S	DO36556	READ	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0833
p.G142R	TCGA-FT-A3EE	BLCA	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6457
p.G142R	DO720	BLCA	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6457
p.G142R	DO50970	LICA	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6457
p.Q154K	TCGA-QR-A707	PCPG	TCGA	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.D145Y	DO229229	THCA	ICGC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6214
p.Y144C	SIDM00524	Small Cell Lung Carcinoma	GDSC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7087
p.Y144C	ACH-000703	Lung Cancer	CCLE	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7087
p.Y144C	DMS-79	lung	COSMIC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7087
p.G142W	SIDM01617	Endometrial Carcinoma	GDSC	VGPYDE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6714

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAHD2A

UniProt ID: Q96GK7

Entrez ID: 51011

Protein name: Fumarylacetoacetate hydrolase domain-containing protein 2A (EC 3.-.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAHD2A in