DegronMD

Uniprot ID: Q96GK7

Source protein: Fumarylacetoacetate hydrolase domain-containing protein 2A

Source gene: FAHD2A

Class: LIG_APCC_ABBA_1

Location: 141:146

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6557

ASA_SCORE: 58.65

COIL: 0.7713

CONS_SCORE: 0.4627

DSS_SCORE: 0.2007

HELIX: 0.0298

FCONS_SCORE: 0.8899

RIG_SCORE: 0.7914

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y144C	SIDM00524	Small Cell Lung Carcinoma	GDSC	VGPYDE	LIG_APCC_ABBA_1	0.7087
p.Y144C	ACH-000703	Lung Cancer	CCLE	VGPYDE	LIG_APCC_ABBA_1	0.7087
p.Y144C	DMS-79	lung	COSMIC	VGPYDE	LIG_APCC_ABBA_1	0.7087
p.E146K	TCGA-CR-7369	HNSC	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.7022
p.E146K	DO14934	HNSC	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.7022
p.P143S	TCGA-AX-A0J1	UCEC	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.6752
p.P143S	DO41199	UCEC	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.6752
p.G142W	SIDM01617	Endometrial Carcinoma	GDSC	VGPYDE	LIG_APCC_ABBA_1	0.6714
p.G142R	TCGA-FT-A3EE	BLCA	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.6457
p.G142R	DO720	BLCA	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.6457
p.G142R	DO50970	LICA	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.6457
p.D145Y	DO229229	THCA	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.6214
p.V141M	TCGA-A5-A0G5	UCEC	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.6097
p.V141M	TCGA-BR-8487	STAD	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.6097
p.V141M	DO47867	STAD	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.6097
p.V141M	DO41416	UCEC	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.6097
p.V141M	SIDM01297	Colorectal Carcinoma	GDSC	VGPYDE	LIG_APCC_ABBA_1	0.6097
p.I140V	TCGA-77-7463	LUSC	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.3056
p.I140V	DO26716	LUSC	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.3056
p.S139F	TCGA-AC-A5XS	BRCA	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.2778
p.S139F	DO50023	BRCA	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.2778
p.A137V	TCGA-BR-4184	STAD	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.2222
p.A137V	DO38328	STAD	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.2222
p.F136C	TCGA-19-5956	GBM	TCGA	VGPYDE	LIG_APCC_ABBA_1	0.1944
p.F136C	DO13863	GBM	ICGC	VGPYDE	LIG_APCC_ABBA_1	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GK7	Fumarylacetoacetate hydrolase domain-containing protein 2A	LIG_APCC_ABBA_1	141:146	VGPYDE	APC,CDC20,FZR1	0.6557	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons