DegronMD - Q96GX2(ATXN7L3B)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P85S	TCGA-AJ-A3EL	UCEC	TCGA	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1389
p.P85S	DO41542	UCEC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1389
p.Q62P	TCGA-W5-AA39	CHOL	TCGA	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.G82W	DO228924	LICA	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2222
p.D66E	DO23406	LINC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2222
p.G68V	DO230961	LUSC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.G68V	DO224594	LUSC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.2778
p.D86N	DO224563	LUSC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111
p.P78T	DO233550	PRAD	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation altering degron motif	0.5919
p.D86H	ACH-001411	Bladder Cancer	CCLE	CRLPLCSLP	DEG_APCC_DBOX_1	70:78	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons