DegronMD

Uniprot ID: Q96GX2

Source protein: Ataxin-7-like protein 3B

Source gene: ATXN7L3B

Class: DEG_APCC_DBOX_1

Location: 70:78

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9834

ASA_SCORE: 51.2333

COIL: 0.7187

CONS_SCORE: 0.7486

DSS_SCORE: 0.4878

HELIX: 0.0361

FCONS_SCORE: 0.9856

RIG_SCORE: 0.7396

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P85S	TCGA-AJ-A3EL	UCEC	TCGA	CRLPLCSLP	DEG_APCC_DBOX_1	0.1389
p.P85S	DO41542	UCEC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.1389
p.Q62P	TCGA-W5-AA39	CHOL	TCGA	CRLPLCSLP	DEG_APCC_DBOX_1	0.1111
p.G82W	DO228924	LICA	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.2222
p.D66E	DO23406	LINC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.2222
p.G68V	DO230961	LUSC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.2778
p.G68V	DO224594	LUSC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.2778
p.D86N	DO224563	LUSC	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.1111
p.P78T	DO233550	PRAD	ICGC	CRLPLCSLP	DEG_APCC_DBOX_1	0.5919
p.D86H	ACH-001411	Bladder Cancer	CCLE	CRLPLCSLP	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96GX2	Ataxin-7-like protein 3B	DEG_APCC_DBOX_1	70:78	CRLPLCSLP	APC,CDC20,FZR1	0.9834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons