DegronMD - Q96HA7(TONSL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D855H	TCGA-43-8118	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2222
p.D855H	DO45471	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2222
p.P909H	TCGA-52-7622	LUSC	TCGA	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7694
p.P909H	DO26764	LUSC	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7694
p.R873C	TCGA-CV-7568	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.R873C	DO14160	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.R873C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.R873C	ACH-000937	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.R873C	PF-382	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.S863Y	TCGA-DF-A2KU	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation altering degron motif	0.8231
p.S863Y	DO223286	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation altering degron motif	0.8231
p.R910M	TCGA-ER-A19G	SKCM	TCGA	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7521
p.R910M	DO45299	LIRI	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7521
p.R910M	DO47284	SKCM	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.7521
p.R873H	TCGA-F1-A448	STAD	TCGA	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.R873H	DO48044	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.P902L	TCGA-FR-A729	SKCM	TCGA	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.2222
p.P902L	DO48618	SKCM	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.2222
p.R849H	DO233156	GACA	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.R849H	ACH-002256	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0556
p.S749N	DO233634	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1111
p.S749N	ACH-000977	lymph node	CCLE	PASSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1111
p.R732M	DO233764	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1944
p.A899T	DO233882	GACA	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.1389
p.S896N	DO233867	GACA	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.D855E	DO228976	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2222
p.P902H	DO229031	LICA	ICGC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.2222
p.S741R	DO229037	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.8538
p.R851W	DO220876	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1111
p.S900L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation blocking phosphorylation signal	0.6111
p.S900L	ACH-000983	Leukemia	CCLE	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation blocking phosphorylation signal	0.6111
p.S900L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation blocking phosphorylation signal	0.6111
p.P872S	SIDM00216	Colorectal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0833
p.P872S	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0833
p.P872S	SNU-175	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.0833
p.P906S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM01144	Gastric Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM01242	Melanoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM01045	Endometrial Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM00214	Colorectal Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM00397	Acute Myeloid Leukemia	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM00566	Oral Cavity Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SIDM01582	Gastric Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	Set2	haematopoietic and lymphoid tissue	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	EN	endometrium	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	SNU-407	large intestine	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	MMAC-SF	skin	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	OSC-19	upper aerodigestive tract	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.P906S	NCI-SNU-5	stomach	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6752
p.E868K	SIDM00685	Glioblastoma	GDSC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1944
p.E868K	ACH-000819	Brain Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1944
p.E868K	LN-18	central nervous system	COSMIC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.1944
p.R857H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2778
p.R857H	ACH-000918	Leukemia	CCLE	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2778
p.R857H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	859:863	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TONSL

UniProt ID: Q96HA7

Entrez ID: 4796

Protein name: Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TONSL in