DegronMD

Uniprot ID: Q96HA7

Source protein: Tonsoku-like protein

Source gene: TONSL

Class: DEG_SCF_FBW7_1

Location: 906:912

E3 ligase: FBXW7

DEGRON score: 0.9686

ASA_SCORE: 95.3

COIL: 0.953

CONS_SCORE: 0.3136

DSS_SCORE: 0.8026

HELIX: 0.0141

FCONS_SCORE: 1.0145

RIG_SCORE: 0.4946

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P909H	TCGA-52-7622	LUSC	TCGA	PSTPRVS	DEG_SCF_FBW7_1	0.7694
p.P909H	DO26764	LUSC	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.7694
p.R910M	TCGA-ER-A19G	SKCM	TCGA	PSTPRVS	DEG_SCF_FBW7_1	0.7521
p.R910M	DO45299	LIRI	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.7521
p.R910M	DO47284	SKCM	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.7521
p.P902L	TCGA-FR-A729	SKCM	TCGA	PSTPRVS	DEG_SCF_FBW7_1	0.2222
p.P902L	DO48618	SKCM	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.2222
p.A899T	DO233882	GACA	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.1389
p.S896N	DO233867	GACA	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.0556
p.P902H	DO229031	LICA	ICGC	PSTPRVS	DEG_SCF_FBW7_1	0.2222
p.S900L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6111
p.S900L	ACH-000983	Leukemia	CCLE	PSTPRVS	DEG_SCF_FBW7_1	0.6111
p.S900L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6111
p.P906S	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM01144	Gastric Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM01242	Melanoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM01045	Endometrial Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM00214	Colorectal Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM00397	Acute Myeloid Leukemia	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM00566	Oral Cavity Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SIDM01582	Gastric Carcinoma	GDSC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	EN	endometrium	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	SNU-407	large_intestine	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	MMAC-SF	skin	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	OSC-19	upper_aerodigestive_tract	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752
p.P906S	NCI-SNU-5	stomach	COSMIC	PSTPRVS	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPRVS

Degron related mutations and impact score

Drug responses associated with TONSL mutations

All proteins holding degron of PSTPRVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HA7	Tonsoku-like protein	DEG_SCF_FBW7_1	906:912	PSTPRVS	FBXW7	0.9686	More...