DegronMD - Q96HJ3(CCDC34)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D80G	TCGA-98-8022	LUSC	TCGA	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.D80G	DO26934	LUSC	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.L70H	TCGA-AX-A2HJ	UCEC	TCGA	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7313
p.L70H	DO42105	UCEC	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7313
p.S68C	TCGA-CF-A1HR	BLCA	TCGA	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.643
p.S68C	DO469	BLCA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.643
p.S65L	DO48368	BLCA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6556
p.P53S	DO230315	COCA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0556
p.P53S	DO234285	ESAD	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0556
p.D80E	DO233140	GACA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.D78H	DO228937	LICA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1389
p.G71V	SIDM01307	Colorectal Carcinoma	GDSC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6421
p.N61D	SIDM01086	B-Lymphoblastic Leukemia	GDSC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.N61D	ACH-000874	Leukemia	CCLE	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.N61D	RS4-11	haematopoietic and lymphoid tissue	COSMIC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.E79D	SIDM01619	Endometrial Carcinoma	GDSC	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.E79D	ACH-000984	Endometrial/Uterine Cancer	CCLE	TRSLLSPLG	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111

Kaplan plot for CCDC34 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC34

UniProt ID: Q96HJ3

Entrez ID: 91057

Protein name: Coiled-coil domain-containing protein 34 (Renal carcinoma antigen NY-REN-41)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC34 in