DegronMD

Uniprot ID: Q96HJ3

Source protein: Coiled-coil domain-containing protein 34

Source gene: CCDC34

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7985

ASA_SCORE: 40.8667

COIL: 0.5316

CONS_SCORE: 0.6248

DSS_SCORE: 0.5592

HELIX: 0.2157

FCONS_SCORE: 1.3978

RIG_SCORE: 0.6358

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D80G	TCGA-98-8022	LUSC	TCGA	TRSLLSPLG	DEG_APCC_DBOX_1	0.0833
p.D80G	DO26934	LUSC	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.0833
p.L70H	TCGA-AX-A2HJ	UCEC	TCGA	TRSLLSPLG	DEG_APCC_DBOX_1	0.7313
p.L70H	DO42105	UCEC	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.7313
p.S68C	TCGA-CF-A1HR	BLCA	TCGA	TRSLLSPLG	DEG_APCC_DBOX_1	0.643
p.S68C	DO469	BLCA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.643
p.S65L	DO48368	BLCA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.6556
p.P53S	DO230315	COCA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.0556
p.P53S	DO234285	ESAD	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.0556
p.D80E	DO233140	GACA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.0833
p.D78H	DO228937	LICA	ICGC	TRSLLSPLG	DEG_APCC_DBOX_1	0.1389
p.G71V	SIDM01307	Colorectal Carcinoma	GDSC	TRSLLSPLG	DEG_APCC_DBOX_1	0.6421
p.N61D	SIDM01086	B-Lymphoblastic Leukemia	GDSC	TRSLLSPLG	DEG_APCC_DBOX_1	0.2778
p.N61D	ACH-000874	Leukemia	CCLE	TRSLLSPLG	DEG_APCC_DBOX_1	0.2778
p.N61D	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	TRSLLSPLG	DEG_APCC_DBOX_1	0.2778
p.E79D	SIDM01619	Endometrial Carcinoma	GDSC	TRSLLSPLG	DEG_APCC_DBOX_1	0.1111
p.E79D	ACH-000984	Endometrial/Uterine Cancer	CCLE	TRSLLSPLG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HJ3	Coiled-coil domain-containing protein 34	DEG_APCC_DBOX_1	63:71	TRSLLSPLG	APC,CDC20,FZR1	0.7985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons