DegronMD - Q96HR3(MED30)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S123T	TCGA-A5-A1OF	UCEC	TCGA	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2222
p.S123T	DO42568	UCEC	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2222
p.E112K	TCGA-BR-4361	STAD	TCGA	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E112K	TCGA-T2-A6X2	HNSC	TCGA	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E112K	DO219071	HNSC	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E112K	DO38887	STAD	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E112K	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E112K	ACH-002393	Lymphoma	CCLE	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.E112K	CRO-AP3	NS	COSMIC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.2778
p.D127N	TCGA-CD-A48C	STAD	TCGA	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1111
p.D127N	TCGA-CG-5733	STAD	TCGA	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1111
p.D127N	DO38551	STAD	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1111
p.D127N	DO47912	STAD	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1111
p.P116L	TCGA-D6-6516	HNSC	TCGA	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.6471
p.P116L	DO15623	HNSC	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.6471
p.D126N	DO229365	BTCA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D126N	DO222771	ESCA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.R128Q	DO233709	GACA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0833
p.R129Q	DO14192	HNSC	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.R129Q	DO33544	PACA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.G122C	DO228948	LICA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.25
p.A129S	DO228976	LICA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.K124N	DO229009	LICA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation substituting flanking lysine	0.3056
p.L114F	DO46824	RECA	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.587
p.I124S	DO41758	UCEC	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation substituting flanking lysine	0.3056
p.Q116H	DO43723	UCEC	ICGC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation altering degron motif	0.7582
p.D107H	SIDM00128	Head and Neck Carcinoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D107H	SIDM00258	Neuroblastoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D107H	SIDM00188	Kidney Carcinoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D107H	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D107H	SIDM01711	Non-Cancerous	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.D107H	SIDM00736	Non-Cancerous	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.A129P	SIDM00656	Burkitt's Lymphoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.A129P	ACH-000944	Lymphoma	CCLE	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.A129P	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.0556
p.D107Y	SIDM00863	Burkitt's Lymphoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1389
p.Q127K	NCI-H1155	lung	COSMIC	LIPYVE	LIG_APCC_ABBA_1	114:119	Mutation rewiring degron network	0.1111

Kaplan plot for MED30 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED30

UniProt ID: Q96HR3

Entrez ID: 90390

Protein name: Mediator of RNA polymerase II transcription subunit 30 (Mediator complex subunit 30) (TRAP/Mediator complex component TRAP25) (Thyroid hormone receptor-associated protein 6) (Thyroid hormone receptor-associated protein complex 25 kDa component) (Trap25)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED30 in