DegronMD

Uniprot ID: Q96HR3

Source protein: Mediator of RNA polymerase II transcription subunit 30

Source gene: MED30

Class: LIG_APCC_ABBA_1

Location: 114:119

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8223

ASA_SCORE: 63.3167

COIL: 0.5527

CONS_SCORE: 0.5614

DSS_SCORE: 0.5338

HELIX: 0.0898

FCONS_SCORE: 1.4365

RIG_SCORE: 0.7864

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S123T	TCGA-A5-A1OF	UCEC	TCGA	LIPYVE	LIG_APCC_ABBA_1	0.2222
p.S123T	DO42568	UCEC	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.2222
p.E112K	TCGA-BR-4361	STAD	TCGA	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.E112K	TCGA-T2-A6X2	HNSC	TCGA	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.E112K	DO219071	HNSC	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.E112K	DO38887	STAD	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.E112K	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.E112K	ACH-002393	Lymphoma	CCLE	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.E112K	CRO-AP3	NS	COSMIC	LIPYVE	LIG_APCC_ABBA_1	0.2778
p.D127N	TCGA-CD-A48C	STAD	TCGA	LIPYVE	LIG_APCC_ABBA_1	0.1111
p.D127N	TCGA-CG-5733	STAD	TCGA	LIPYVE	LIG_APCC_ABBA_1	0.1111
p.D127N	DO38551	STAD	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.1111
p.D127N	DO47912	STAD	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.1111
p.P116L	TCGA-D6-6516	HNSC	TCGA	LIPYVE	LIG_APCC_ABBA_1	0.6471
p.P116L	DO15623	HNSC	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.6471
p.D126N	DO229365	BTCA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.D126N	DO222771	ESCA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.R128Q	DO233709	GACA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.0833
p.R129Q	DO14192	HNSC	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.0556
p.R129Q	DO33544	PACA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.0556
p.G122C	DO228948	LICA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.25
p.A129S	DO228976	LICA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.0556
p.K124N	DO229009	LICA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.3056
p.L114F	DO46824	RECA	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.587
p.I124S	DO41758	UCEC	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.3056
p.Q116H	DO43723	UCEC	ICGC	LIPYVE	LIG_APCC_ABBA_1	0.7582
p.D107H	SIDM00128	Head and Neck Carcinoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.D107H	SIDM00258	Neuroblastoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.D107H	SIDM00188	Kidney Carcinoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.D107H	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.D107H	SIDM01711	Non-Cancerous	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.D107H	SIDM00736	Non-Cancerous	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.A129P	SIDM00656	Burkitt's Lymphoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.0556
p.A129P	ACH-000944	Lymphoma	CCLE	LIPYVE	LIG_APCC_ABBA_1	0.0556
p.A129P	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LIPYVE	LIG_APCC_ABBA_1	0.0556
p.D107Y	SIDM00863	Burkitt's Lymphoma	GDSC	LIPYVE	LIG_APCC_ABBA_1	0.1389
p.Q127K	NCI-H1155	lung	COSMIC	LIPYVE	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIPYVE

Degron related mutations and impact score

Drug responses associated with MED30 mutations

All proteins holding degron of LIPYVE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HR3	Mediator of RNA polymerase II transcription subunit 30	LIG_APCC_ABBA_1	114:119	LIPYVE	APC,CDC20,FZR1	0.8223	More...