DegronMD - Q96HS1(PGAM5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E84Q	TCGA-05-5428	LUAD	TCGA	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2778
p.E84Q	DO24005	LUAD	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2778
p.L85V	TCGA-67-3771	LUAD	TCGA	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.25
p.L85V	DO25797	LUAD	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.25
p.R74W	TCGA-AX-A06F	UCEC	TCGA	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.25
p.R74W	DO41752	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.25
p.G81V	TCGA-D3-A2JC	SKCM	TCGA	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7532
p.G81V	DO47578	SKCM	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7532
p.S87A	TCGA-D8-A1XQ	BRCA	TCGA	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation blocking phosphorylation signal	0.6389
p.S87A	DO3095	BRCA	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation blocking phosphorylation signal	0.6389
p.E72D	DO229015	LICA	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.1944
p.G81W	DO229037	LICA	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7825
p.I79M	DO48897	PBCA	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation altering degron motif	0.7618
p.V89M	DO36531	READ	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.1389
p.V89M	DO42280	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.1389
p.R86S	DO37405	SKCM	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.A68T	DO223282	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.0833
p.A68T	DO42568	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.0833
p.V84I	DO41871	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2778
p.V73M	SIDM00217	Colorectal Carcinoma	GDSC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.V73M	ACH-000999	Colon/Colorectal Cancer	CCLE	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.V73M	SNU-1040	large intestine	COSMIC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.R86H	ACH-000999	Colon/Colorectal Cancer	CCLE	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222
p.R86H	SNU-1040	large intestine	COSMIC	NVESGE	DEG_Kelch_Keap1_1	77:82	Mutation rewiring degron network	0.2222

Kaplan plot for PGAM5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PGAM5

UniProt ID: Q96HS1

Entrez ID: 192111

Protein name: Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PGAM5 in