DegronMD

Uniprot ID: Q96HS1

Source protein: Serine/threonine-protein phosphatase PGAM5, mitochondrial

Source gene: PGAM5

Class: DEG_Kelch_Keap1_1

Location: 77:82

E3 ligase: KEAP1

DEGRON score: 0.9835

ASA_SCORE: 90.9

COIL: 0.7307

CONS_SCORE: 0.3183

DSS_SCORE: 0.3486

HELIX: 0.251

FCONS_SCORE: 1.0254

RIG_SCORE: 0.6994

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G81W	DO229037	LICA	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.7825
p.I79M	DO48897	PBCA	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.7618
p.G81V	TCGA-D3-A2JC	SKCM	TCGA	NVESGE	DEG_Kelch_Keap1_1	0.7532
p.G81V	DO47578	SKCM	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.7532
p.S87A	TCGA-D8-A1XQ	BRCA	TCGA	NVESGE	DEG_Kelch_Keap1_1	0.6389
p.S87A	DO3095	BRCA	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.6389
p.E84Q	TCGA-05-5428	LUAD	TCGA	NVESGE	DEG_Kelch_Keap1_1	0.2778
p.E84Q	DO24005	LUAD	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.2778
p.V84I	DO41871	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.2778
p.L85V	TCGA-67-3771	LUAD	TCGA	NVESGE	DEG_Kelch_Keap1_1	0.25
p.L85V	DO25797	LUAD	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.25
p.R74W	TCGA-AX-A06F	UCEC	TCGA	NVESGE	DEG_Kelch_Keap1_1	0.25
p.R74W	DO41752	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.25
p.R86S	DO37405	SKCM	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.2222
p.V73M	SIDM00217	Colorectal Carcinoma	GDSC	NVESGE	DEG_Kelch_Keap1_1	0.2222
p.V73M	ACH-000999	Colon/Colorectal Cancer	CCLE	NVESGE	DEG_Kelch_Keap1_1	0.2222
p.V73M	SNU-1040	large_intestine	COSMIC	NVESGE	DEG_Kelch_Keap1_1	0.2222
p.R86H	ACH-000999	Colon/Colorectal Cancer	CCLE	NVESGE	DEG_Kelch_Keap1_1	0.2222
p.R86H	SNU-1040	large_intestine	COSMIC	NVESGE	DEG_Kelch_Keap1_1	0.2222
p.E72D	DO229015	LICA	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.1944
p.V89M	DO36531	READ	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.1389
p.V89M	DO42280	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.1389
p.A68T	DO223282	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.0833
p.A68T	DO42568	UCEC	ICGC	NVESGE	DEG_Kelch_Keap1_1	0.0833

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96HS1	Serine/threonine-protein phosphatase PGAM5, mitochondrial	DEG_Kelch_Keap1_1	77:82	NVESGE	KEAP1	0.9835	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons