DegronMD - Q96I13(ABHD8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K155R	TCGA-CR-6474	HNSC	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.6126
p.K155R	DO14542	HNSC	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.6126
p.K155N	TCGA-CV-A463	HNSC	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.6918
p.K155N	DO52066	HNSC	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.6918
p.T157I	TCGA-EE-A2MS	SKCM	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.5966
p.T157I	DO37567	SKCM	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.5966
p.R148Q	TCGA-VQ-A91D	STAD	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.1389
p.R148Q	DO51783	STAD	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.1389
p.G145D	DO234466	ESAD	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.0556
p.A151D	DO228976	LICA	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.2222
p.R165H	DO232761	PBCA	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.2222
p.R147W	DO232761	PBCA	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.1111
p.E163K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.2778
p.E163K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.2778
p.G171C	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.0556
p.G171C	ACH-000980	Lung Cancer	CCLE	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.0556
p.G171C	NCI-H1155	lung	COSMIC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.0556
p.K155E	SIDM00118	Colorectal Carcinoma	GDSC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.7022
p.K155E	ACH-001081	Colon/Colorectal Cancer	CCLE	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.7022
p.K155E	HCC2998	large intestine	COSMIC	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation altering degron motif	0.7022
p.R150G	ACH-000396	Bladder Cancer	CCLE	KRTIHID	LIG_APCC_ABBAyCdc20_2	155:161	Mutation rewiring degron network	0.1944

Kaplan plot for ABHD8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABHD8

UniProt ID: Q96I13

Entrez ID: 79575

Protein name: Protein ABHD8 (EC 3.-.-.-) (Alpha/beta hydrolase domain-containing protein 8) (Abhydrolase domain-containing protein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABHD8 in