DegronMD

Uniprot ID: Q96I13

Source protein: Protein ABHD8

Source gene: ABHD8

Class: LIG_APCC_ABBAyCdc20_2

Location: 155:161

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7763

ASA_SCORE: 82.9429

COIL: 0.338

CONS_SCORE: 0.3798

DSS_SCORE: 0.507

HELIX: 0.0033

FCONS_SCORE: 1.1203

RIG_SCORE: 0.7949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K155R	TCGA-CR-6474	HNSC	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.6126
p.K155R	DO14542	HNSC	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.6126
p.K155N	TCGA-CV-A463	HNSC	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.6918
p.K155N	DO52066	HNSC	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.6918
p.T157I	TCGA-EE-A2MS	SKCM	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.5966
p.T157I	DO37567	SKCM	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.5966
p.R148Q	TCGA-VQ-A91D	STAD	TCGA	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.1389
p.R148Q	DO51783	STAD	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.1389
p.G145D	DO234466	ESAD	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.0556
p.A151D	DO228976	LICA	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.2222
p.R165H	DO232761	PBCA	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.2222
p.R147W	DO232761	PBCA	ICGC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.1111
p.E163K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.2778
p.E163K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.2778
p.G171C	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.0556
p.G171C	ACH-000980	Lung Cancer	CCLE	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.0556
p.G171C	NCI-H1155	lung	COSMIC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.0556
p.K155E	SIDM00118	Colorectal Carcinoma	GDSC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.7022
p.K155E	ACH-001081	Colon/Colorectal Cancer	CCLE	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.7022
p.K155E	HCC2998	large_intestine	COSMIC	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.7022
p.R150G	ACH-000396	Bladder Cancer	CCLE	KRTIHID	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96I13	Protein ABHD8	LIG_APCC_ABBAyCdc20_2	155:161	KRTIHID	APC,CDC20,FZR1	0.7763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons