DegronMD - Q96I76(GPATCH3)

FUNCTION: Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting vi... View more >>

GO - Biological processes (BP): negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; positive regulation of transcription, DNA-templated [GO:0045893]

GO - Molecular function (MF): nucleic acid binding [GO:0003676]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R471I	TCGA-DK-A6AW	BLCA	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.8102
p.R471I	DO48566	BLCA	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.8102
p.L474F	TCGA-ER-A2NF	SKCM	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.6981
p.L474F	DO47451	SKCM	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation altering degron motif	0.6981
p.Y481H	DO229240	THCA	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.25
p.E483K	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1944
p.E483K	ACH-000942	Leukemia	CCLE	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1944
p.P484H	TCGA-B5-A3FC	UCEC	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.P484H	DO41871	UCEC	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.G464W	TCGA-DU-6392	LGG	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.G464W	DO22237	LGG	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1667
p.F463C	TCGA-BR-8680	STAD	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1389
p.F463C	DO47769	STAD	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.1389
p.D488Y	SIDM00193	Colorectal Carcinoma	GDSC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.0556
p.D488Y	ACH-000991	Colon/Colorectal Cancer	CCLE	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.0556
p.D488Y	SNU-81	large intestine	COSMIC	RRNGLGLIS	DEG_APCC_DBOX_1	470:478	Mutation rewiring degron network	0.0556

Showing 1 to 16 of 16 entries

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No resistance data available for this Degron.

Kaplan plot for GPATCH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPATCH3

UniProt ID: Q96I76

Entrez ID: 63906

Protein name: G patch domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for GPATCH3 in